A structured pre-clinical research program
Bacosane® is supported by pre-clinical studies investigating neurological activity, stress-related behaviour, antioxidant capacity and safety — in vitro testing, multiple animal models and acute plus subacute oral toxicity evaluations.
Current pre-clinical evidence
| Study area | Design | Model | Dose | Key reported outcome |
|---|---|---|---|---|
| Anticonvulsant activity | In vivo MES and PTZ models | Albino rats and mice | 50 and 100 mg/kg | Dose-responsive activity; 67% protection at 50 mg/kg and 84% protection at 100 mg/kg in the PTZ model. |
| Anxiolytic activity (Actophotometer) | Actophotometer method | Male and female Wistar rats | 50 and 100 mg/kg | Significant reduction in immobility time and dose-dependent anti-anxiety effects. |
| Anxiolytic activity (Elevated Plus Maze) | Elevated Plus Maze test | Wistar rats (n=6 per group) | 50 and 100 mg/kg | Increased open-arm entries (up to 49.2%) and time in open arms vs. control. |
| Antioxidant activity | In vitro DPPH assay | Laboratory assay vs BHT | Concentration-dependent | IC50 150.50 µg/mL (BHT reference 87.25 µg/mL); supports SOD, CAT, GPX, GSR. |
| Acute oral toxicity | In vivo safety study | Albino rats | 5,000 mg/kg | No mortality, apparent toxicity or significant differences (p > 0.05) vs control. |
| Subacute oral toxicity | 28-day repeated dose | Albino rats | 250, 500 and 1,000 mg/kg | No mortality, organ toxicity or significant differences (p > 0.05) in biochemistry or hematology. |
This index summarizes preclinical research across validated animal and laboratory models, establishing a rigorous scientific baseline for ongoing human clinical trials.
Detailed scientific dossiers
Pre-Clinical Dossier
Complete in vivo & in vitro charts, animal models, and molecular docking.
Mechanism of Action
Synaptic restoration, neurotransmitter modulation, and antioxidant enzyme pathways.
Safety & Quality
Acute & sub-acute safety data, batch release standards, and QA testing.
Clinical Progress
Current status, study designs, and human clinical trial roadmap.
Download the Bacosane® research dossier
Access the preclinical efficacy, mechanistic, safety and patent documentation for technical review.